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- Title
Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment.
- Authors
Kanauchi, Osamu; Serizawa, Isao; Araki, Yoshio; Suzuki, Asuka; Andoh, Akira; Fujiyama, Yoshihide; Mitsuyama, Keiichi; Takaki, Kosuke; Toyonaga, Atsushi; Sata, Michio; Bamba, Tadao
- Abstract
Background. Germinated barley foodstuff (GBF), which contains glutamine-rich protein and hemicellulose-rich fiber, exhibits therapeutic effects in ulcerative colitis; however, its mechanism is still under investigation. The aim of this study was to evaluate the antiinflammatory effects of GBF on colitis in terms of the epithelial inflammatory response. Methods. Mice with dextran sulfate sodium-induced colitis were used. The effects of GBF on the colitis were evaluated by measuring the body weight; disease activity; mucosal damage (histology, mucosal inflammatory parameters, nuclear factor kappa B [NFkB] activation, and signal transducer and activator of transcription 3 [STAT3]); serum interleukin 6 (IL-6) level; cecal short-chain fatty acids (SCFAs); and bile acid contents. Results. GBF significantly prevented disease activity and body weight loss after induction of colitis. Serum IL-6 level and mucosal STAT3 expression were also significantly attenuated, with a conspicuous reduction of mucosal damage; NFkB activity showed the same tendency. Cecal butyrate content was significantly higher and, interestingly, GBF mice had lower bile acid concentrations than the control group. Conclusions. GBF has the potential to reduce the epithelial inflammatory response by depressing STAT-3 expression and inhibiting NFkB binding activity. These effects may be brought about by an increase of butyrate production and adsorption of bile acids.
- Subjects
COLITIS; BARLEY; ANTI-inflammatory agents
- Publication
Journal of Gastroenterology, 2003, Vol 38, Issue 2, p134
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s005350300022