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- Title
Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature.
- Authors
Maierean, Anca Diana; Bordea, Ioana Roxana; Salagean, Tudor; Hanna, Reem; Alexescu, Teodora Gabriela; Chis, Ana; Todea, Doina Adina
- Abstract
Background: Obstructive sleep apnea (OSA) is a highly prevalent disease with substantial public health burden. In most of the cases, there is a genetic predisposition to OSA. Serotonin/T-HydroxyTriptamine (5-HT) plays a key role in ventilatory stimulation, while the polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level, making it important in OSA. Objective: To examine whether the 5-HydroxyTriptamine and the genetic predisposition influence the incidence and evolution of OSA, we reviewed randomized, controlled trials and observational studies on the selected topic. The secondary objective was to determine the metabolic effects of the circulating serotonin in other tissues (liver, pancreas, gut, brown adipose tissue, and white adipose tissue) and its role in the development of obesity. Data Sources: A systematic review of English articles was performed based on PubMed and the Cochrane Library databases. Search filters included randomized controlled trial, controlled clinical trial, random allocation, double-blind method, and case–control studies and used the following
- Subjects
SEROTONIN transporters; SLEEP apnea syndromes; SEROTONIN; WHITE adipose tissue; BROWN adipose tissue; ADIPOSE tissues; PANCREAS
- Publication
Nature & Science of Sleep, 2021, Vol 13, p125
- ISSN
1179-1608
- Publication type
Article
- DOI
10.2147/NSS.S278170