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- Title
Accelerated partial breast irradiation in a single 18 Gy fraction with high-dose-rate brachytherapy: preliminary results.
- Authors
Latorre, Javier Anchuelo; Galdós, Piedad; Buznego, Lucía Alonso; Blanco, Ana García; Cardenal, Juan; Ferri, María; de Cerio, Iván Díaz; Arrojo, Elisabet; Sierrasesúmaga, Nicolás; González Noriega, Mónica; De Juan Ferré, Ana; Fabregat, Rosa; Ruíz, Samuel; Prada, Pedro J.
- Abstract
Purpose: To evaluate the feasibility of acute and chronic toxicity in patients suitable for accelerated partial breast irradiation (APBI) in a single 18 Gy fraction with multicatheter high-dose-rate (HDR) brachytherapy, as well as cosmetic and oncological outcomes. Material and methods: Between September 2014 and March 2016, twenty consecutive patients with low-risk invasive and ductal carcinoma in situ were treated with interstitial multicatheter HDR brachytherapy in a single 18 Gy fraction. Results: Median age was 63.5 years (range, 51-79). Acute toxicity was observed in seven patients, while the pain during following days and hematoma were seen in four patients. With a median follow-up of 24 months, late toxicity was found in one patient with fat necrosis g2 and fibrosis g2 in another patient. The overall survival (OS) and locoregional control (LC) was 100%. Disease-free survival (DFS) and distant control was 95%. Good to excellent cosmetic outcomes were noted in 80% of patients and fair in 4 patients (20%). Conclusions: This is the first report in the medical literature that focuses on feasibility and acute and chronic toxicity, with a median follow-up of 24 months (range, 20-40). The protocol is viable and convenient. However, a longer follow-up is needed to know chronic toxicity and oncologic outcomes.
- Subjects
HIGH dose rate brachytherapy; RADIOISOTOPE brachytherapy; BREAST cancer; BREAST cancer treatment; PROSTATE cancer treatment
- Publication
Journal of Contemporary Brachytherapy, 2018, Vol 10, Issue 1, p58
- ISSN
1689-832X
- Publication type
Article
- DOI
10.5114/jcb.2018.73994