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- Title
Donor age and degree of HLA matching have a major impact on the outcome of unrelated donor haematopoietic cell transplantation for chronic myeloid leukaemia.
- Authors
Carreras, E.; Jiménez, M.; Gómez-García, V; de la Cámara, R.; Martín, C.; Martínez, F.; Iriondo, A.; Sanz, G.; Cañizo, C.; Cabrera, R.; Sierra, J.; Vallejo, C.; López, J.; Martínez, C.; Rovira, M.; Fernández-Rañada, J. M.; Torres, A.
- Abstract
We analysed the outcome of 92 consecutive unrelated donor haematopoietic cell transplantations (UD-HC Ts) performed in Spain to treat adult patients with CML in the first chronic phase (1CP). Patients' and donors' median age was 32 (15-49) and 36 (22-56) years, respectively. in all, 73 pairs (79%) matched for A, B ± C and DRB1 ± DQB1 loci and 19 had ⩾ 1 mismatch. Their probability of survival and disease-free survival at 4 years were 50 and 46%, respectively. Pretransplant factors associated with a better survival were patient age <25 years (P = 0.035), donor age ⩽ 36 years (P = 0.012), use of cyclosporine since day -7 (P = 0.001), and matching 8/8, 9/10 or 10/10 loci at allele level (P = 0.003). In multivariate analysis only donor age (P = 0.003; RR = 3.1 (95% CI: 1.3-7.1)) and degree of HLA-matching (P=0.009; RR: 7.7 (95% CI: 1.8-33)) maintained their significance. The addition of these two variables to the EBMT prognostic score allowed an adequate risk assessment for patients receiving a UD-HCT during 1CP. Our analysis shows that in patients with a young and fully allele-matched donor, UD-HCT should be considered in the initial therapeutic algorithm due to its excellent outcome (92% survival at 2 years).
- Subjects
LEUKEMIA; CELL transplantation; BLOOD donors; RISK assessment; IMMUNOSUPPRESSIVE agents; PATIENTS
- Publication
Bone Marrow Transplantation, 2006, Vol 37, Issue 1, p33
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705195