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- Title
Rapid engraftment after allogeneic ABO-incompatible peripheral blood progenitor cell transplantation complicated by severe hemolysis.
- Authors
Bornhäuser, M; Ordemann, R; Paaz, U; Schuler, U; Kömpf, J; Hölig, K; Ehninger, G
- Abstract
A patient with CML in accelerated phase received G-CSF-mobilized PBPC from an unrelated HLA genotypically matched donor. The blood groups of the patient and donor were bidirectionally incompatible. Hematologic recovery was rapid with >500 PMN/μ l on day +9. Starting on day +5 bilirubin levels increased from 1.3 mg/dl up to a maximum of 18 mg/dl on day +14. Clinical signs and laboratory tests supported major hemolysis. Blood typing on day +16 revealed early blood-group change, consistent with donor-derived antibodies produced by passenger-lymphocytes which may have mediated severe hemolysis. The early onset and strong intensity of the hyperbilirubinemia could be a specific feature of ABO-incompatible allogeneic PBPC transplantation which would be difficult to differentiate from GVHD or VOD.
- Subjects
HEMOLYSIS &; hemolysins; HYPERBILIRUBINEMIA; BILIRUBIN
- Publication
Bone Marrow Transplantation, 1997, Vol 19, Issue 3, p295
- ISSN
0268-3369
- Publication type
Article