We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism.
- Authors
Burne, Thomas H. J.; Eyles, Darryl W.; McGrath, John J.
- Abstract
Crespi & Badcock (C&B) present an appealing and parsimonious synthesis arguing that schizophrenia and autism are differentially regulated by maternal versus paternal genomic imprinting, respectively. We argue that animal models related to schizophrenia and autism provide a useful platform to explore the mechanisms outlined by C&B. We also note that schizophrenia and autism share certain risk factors such as advanced paternal age. Apart from genomic imprinting, copy number variants related to advanced paternal age may also contribute to the differential trajectory of brain development associated with autism and schizophrenia.
- Subjects
SCHIZOPHRENIA; AUTISM; PSYCHOSES; DEVELOPMENTAL disabilities; GENOMIC imprinting; PATHOLOGICAL psychology
- Publication
Behavioral & Brain Sciences, 2008, Vol 31, Issue 3, p264
- ISSN
0140-525X
- Publication type
Article
- DOI
10.1017/S0140525X08004251