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- Title
The molecular origin and taxonomy of mucinous ovarian carcinoma.
- Authors
Cheasley, Dane; Wakefield, Matthew J.; Ryland, Georgina L.; Allan, Prue E.; Alsop, Kathryn; Amarasinghe, Kaushalya C.; Ananda, Sumitra; Anglesio, Michael S.; Au-Yeung, George; Böhm, Maret; Bowtell, David D. L.; Brand, Alison; Chenevix-Trench, Georgia; Christie, Michael; Chiew, Yoke-Eng; Churchman, Michael; DeFazio, Anna; Demeo, Renee; Dudley, Rhiannon; Fairweather, Nicole
- Abstract
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases. Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
- Subjects
MUCINOUS adenocarcinoma; OVARIAN tumors; GENETIC disorders; ETIOLOGY of cancer; OVARIAN cancer; APPENDIX (Anatomy)
- Publication
Nature Communications, 2019, Vol 10, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-019-11862-x