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- Title
Pharmacological rescue of diabetic skeletal stem cell niches.
- Authors
Tevlin, Ruth; Eun Young Seo; Marecic, Owen; McArdle, Adrian; Xinming Tong; Zimdahl, Bryan; Malkovski, Andrey; Sinha, Rahul; Gulati, Gunsagar; Xiyan Li; Wearda, Taylor; Morganti, Rachel; Lopez, Michael; Ransom, Ryan C.; Duldulao, Christopher R.; Rodrigues, Melanie; Nguyen, Allison; Januszyk, Michael; Maan, Zeshaan; Paik, Kevin
- Abstract
The article presents a study which analyzed intrinsic and extrinsic determinants of mouse skeletal stem cell (mSSC) function to identify specific mSSC-related abnormalities that could impair skeletal repair in diabetic mice. Topics discussed include link between diabetes mellitus and impaired bone healing, molecular characterization of the skeletal niche points to therapeutic strategies, and isolation of skeletal progenitor cells.
- Subjects
STEM cells; DIABETES; WOUND healing; PROGENITOR cells; LABORATORY mice
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 372, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aag2809