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- Title
Better Progression-Free Survival in Elderly Patients with Stage IV Lung Adenocarcinoma Harboring Uncommon Epidermal Growth Factor Receptor Mutations Treated with the First-line Tyrosine Kinase Inhibitors.
- Authors
Tsai, Ming-Ju; Hung, Jen-Yu; Lee, Mei-Hsuan; Kuo, Chia-Yu; Tsai, Yu-Chen; Tsai, Ying-Ming; Liu, Ta-Chih; Yang, Chih-Jen; Huang, Ming-Shyan; Chong, Inn-Wen
- Abstract
Patients with lung adenocarcinoma harboring common epidermal growth factor receptor (EGFR) mutations usually have a good response rate (RR) and longer progression-free survival (PFS) to EGFR tyrosine kinase inhibitors (TKIs). However, the treatment efficacy to uncommon EGFR mutations remains controversial. We, therefore, performed a retrospective study, screening 2958 patients. A total of 67 patients with lung adenocarcinoma harboring uncommon EGFR mutations were enrolled and 57 patients with stage IV diseases receiving a first-line EGFR TKI were included for further analyses. The patients were classified into 27 (47%) "a single sensitizing uncommon mutation", 7 (12%) "multiple sensitizing mutations", 5 (9%) "a sensitizing mutation and a resistant uncommon mutation", and 18 (32%) "other resistant uncommon mutations". No significant difference was noted in PFS or overall survival (OS) between groups. Patients receiving different first-line EGFR TKIs had similar PFS and OS. The elder patients had a significantly poorer performance status than the younger patients but a significantly longer PFS than the younger patients (median PFS: 10.5 vs. 5.5 months, p = 0.0320). In conclusion, this is the first study to identify that elderly patients with stage IV lung adenocarcinoma harboring uncommon EGFR mutation might have a longer PFS. Large-scale prospective studies are mandatory to prove our findings.
- Subjects
PROTEIN-tyrosine kinase inhibitors; EPIDERMAL growth factor; ADENOCARCINOMA; GENETIC mutation; LUNG tumors; SURVIVAL; TUMOR classification; RETROSPECTIVE studies; DISEASE progression; EARLY detection of cancer; OLD age; DIAGNOSIS; PROGNOSIS; THERAPEUTICS
- Publication
Cancers, 2018, Vol 10, Issue 11, p434
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers10110434