We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evolutionary Origin of OwlRep, aMegasatellite DNA Associated with Adaptation of OwlMonkeys to Nocturnal Lifestyle.
- Authors
Hidenori Nishihara; Stanyon, Roscoe; Junko Kusumi; Hirohisa Hirai; Akihiko Koga
- Abstract
Rod cells of many nocturnal mammals have a "non-standard" nuclear architecture, which is called the inverted nuclear architecture. Heterochromatin localizes to the central region of the nucleus. This leads to an efficient light transmission to the outer segments of photoreceptors. Rod cells of diurnalmammals have the conventional nuclear architecture. Owlmonkeys (genus Aotus) are the only taxon of simian primates that has a nocturnal or cathemeral lifestyle, and this adaptation iswidely thought to be secondary. Their rod cells were shown to exhibit an intermediate chromatin distribution: a spherical heterochromatin block was found in the central region of the nucleus although it was less complete than that of typical nocturnal mammals. We recently demonstrated that the primary DNA component of this heterochromatin block was OwlRep, a megasatellite DNA consisting of 187-bp-long repeat units. However, the origin of OwlRep was not known. Here we show that OwlRep was derived from HSAT6, a simple repeat sequence found in the centromere regions of human chromosomes. HSAT6 occurs widely in primates, suggesting that it was already present in the last common ancestor of extant primates. Notably, Strepsirrhini and Tarsiformes apparently carry a single HSAT6 copy, whereas many species of Simiiformes contain multiple copies. Comparison of nucleotide sequences of these copies revealed the entire process of the OwlRep formation.HSAT6,with orwithout flanking sequences, was segmentally duplicated in New World monkeys. Then, in theowl monkey linage after its divergence from other New World monkeys, a copy of HSAT6 was tandemly amplified, eventually forming a megasatellite DNA.
- Subjects
NIGHT monkeys; BIOLOGICAL evolution; HETEROCHROMATIC genes; DNA; MOLECULAR biology
- Publication
Genome Biology & Evolution, 2018, Vol 10, Issue 1, p157
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evx281