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- Title
Effectiveness of Recombinant Human Erythropoietin Therapy in Myelodysplastic Syndromes.
- Authors
Adamson, J.W.; Schuster, M.; Allen, S.; Haley, N.R.
- Abstract
In an attempt to determine predictors of response to recombinant human erythropoietin (r-HuEPO) therapy in 20 patients with various subtypes of myelodysplastic syndrome (MDS), plasma concentrations of transferrin receptor protein were measured before and after 4 doses of r-HuEPO. An r-HuEPO dosage of 150 U/kg was administered subcutaneously 3 times weekly and increased to 300 U/kg in patients who failed to raise plasma concentrations of transferrin receptor protein by at least one third. Ten (50%) patients had an effective clinical response to therapy by reducing ( > 50%) or eliminating transfusion requirements, or by showing an improvement in haematocrit of ≥6 percentage points. Changes in plasma transferrin receptor protein concentrations failed to predict which patients would eventually respond to r-HuEPO therapy. A subset of MDS patients demonstrated a delayed response to therapy in order to achieve a satisfactory clinical outcome. Precise predictors of response, either laboratory or clinical, remain to be determined. Continued research is warranted in this group of patients in order to specifically target r-HuEPO therapy. It is, however, likely that r-HuEPO therapy will have an effective and important role in this subset of MDS patients. Copyright © 1992 S. Karger AG, Basel
- Publication
Acta Haematologica, 1992, Vol 87, Issue S1, p20
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204784