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- Title
Antitumor Activity of β-glucan Extracted from Pleurotus Eryngii.
- Authors
Al-Saffar, Ali Z.; Hadi, Noora A.; Khalaf, Hadeel Mohamed
- Abstract
Pleurotus eryngii, a type of edible mushroom that exhibit various pharmacological properties, including antioxidant and anticancer effects. In the present study, extracted β-glucan from the P. eryngii was tested as an antioxidant and anti-tumor factor. β-glucan was extracted and analyzed by HPLC and FT-IR. Analytical results showed more than 90% similarity in chemical structure and purity. Potential antioxidant activity of β-glucan was examined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and compared with ascorbic acid. β-glucan confirmed a potential scavenging activity. The anticancer activity of theβ-glucan was assessed using different concentrations (6.25 to 400 μgmL-1) on MCF-7 and HepG2 cell lines. P. eryngiiβ-glucan exerted a dose-dependent reduction in MCF-7 and HepG2 cell viability with an IC50 of 280.00 and 539.5 μg mL-1, respectively. At the same time, no significant effect was recorded on normal cell line WRL 68. The obtained results are expected that could be used to develop P. eryngiiβ-glucanas an antitumor drug.
- Subjects
PLEUROTUS; ANTIOXIDANT testing; CELL lines; HIGH performance liquid chromatography; CHEMICAL structure; VITAMIN C; EDIBLE mushrooms
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2020, Vol 14, Issue 3, p2492
- ISSN
0973-9122
- Publication type
Article
- DOI
10.37506/ijfmt.v14i3.10811