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- Title
EFEITOS DA EXPOSIÇÃO AO DESOXINIVALENOL E NIVALENOL ISOLADOS OU EM ASSOCIAÇÃO EM EXPLANTES INTESTINAIS DE SUÍNOS.
- Authors
Moreira, Jéssica Regina; Rubira Gerez, Juliana; Loureiro Bracarense, Ana Paula; Desto, Stela; Kolf-Clauw, Martine
- Abstract
Deoxynivalenol (DON) and nivalenol (NIV) are trichothecenes mycotoxins produced by Fusarium species, naturally co-occuring in food and feed. The gastrointestinal tract represents the first barrier as well as the first target for these toxicants. The aim of the present study was to characterize the effects of DON and NIV, alone or in combination, on the intestinal tissue of pig. Crossbreed weanling piglets of 24 days-old (n = 6) were used for explanting jejunal tissue. Explants were exposed to 0.1; 0.3; 1; 3 e 10 e 30μM of DON or NIV, or of the mixture DON+NIV (1:1) for 4 hours. The individual treatment with the mycotoxins DON and NIV resulted in a significant decrease of the histopathological score from doses of 10μM and 1μM, respectively. The DON+NIV combination demonstrated synergism for IC50 whereas antagonism was observed at the lower doses. The present results suggest that Fusarium toxins alone may not predict their effects in environment where the combinations of toxins are frequently observed. The present study indicates that the effects of the association of mycotoxins are not similar to the isolated effects, parameters that consider multi-contamination, which are common in natural contaminations, have to be established.
- Subjects
DEOXYNIVALENOL; NIVALENOL; PHYSIOLOGICAL effects of mycotoxins; INTESTINES; JEJUNUM; VETERINARY histopathology; LABORATORY swine
- Publication
Archives of Veterinary Science, 2013, Vol 18, Issue 3, p228
- ISSN
1517-784X
- Publication type
Article