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- Title
Hexafluoroisopropanol Promoted Ring‐Opening‐Cyclization of Donor–Acceptor Cyclopropanes with Primary Amines.
- Authors
Yaragorla, Srinivasarao; Tangellapally, Rajeshwari; Arun, Doma
- Abstract
We reveal here a catalyst‐free, ring‐opening‐cyclization of donor‐acceptor cyclopropanes with primary amines to synthesize functionalized dihydropyrroles. This protocol avoids inert conditions and solvents promoted by hexafluoroisopropanol (HFIP). The reaction is quite general with aryl, alkyl, and alicyclic amines. A good number of cyclopropanes bearing keto groups reacted excellently to produce the desired products. Further, we complemented this method with Meldrum's acid‐derived cyclopropanes for synthesizing γ‐lactams. We have demonstrated the post‐synthetic applications of the products and gram‐scale synthesis to highlight the adaptability of this synthetic protocol.
- Subjects
AMINES; SOLVENTS; RING formation (Chemistry)
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 22, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400238