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- Title
Nitration of Pyrrolo[2,1‐a]isoquinolines with NaNO<sub>2</sub>/HFIP.
- Authors
Huang, Xiang; Li, Yun‐Meng; Zhou, Jing; Pan, Yu‐Yi; Li, Wei; Chen, Xiao‐Hui; Yu, Xin; Pei, Shu‐Chen; Cui, Hai‐Lei
- Abstract
A mild nitration of pyrrolo[2,1‐a]isoquinolines has been reached using sodium nitrite as nitro source in HFIP at ambient temperature. A variety of nitro‐bearing pyrrolo[2,1‐a]isoquinoline derivatives has been efficiently prepared in poor to quantitative yields (28–98 %). These products can be easily transformed to primary amines and amide by simple chemical reactions. Treatment of other nitrogen‐containing heterocycles such as pyrrolo[1,2‐a]quinoline and substituted indoles under this developed reaction system afforded nitro‐bearing N‐heterocycles in relatively lower yields (15–19 %).
- Subjects
QUINOLINE; NITRATION; SODIUM nitrites; CHEMICAL reactions; ISOQUINOLINE; HETEROCYCLIC compounds
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 16, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400116