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- Title
Access to Secondary Amines through Hydrogen Autotransfer Reaction Mediated by KO<sup>t</sup>Bu.
- Authors
P, Hima; Tomasini, Michele; M, Vageesh; Poater, Albert; Dey, Raju
- Abstract
We report herein an N‐alkylation reaction of amines with alcohols through a hydrogen autotransfer reaction. Unlike other catalytic systems containing transition metals or additives, potassium tertiary butoxide was found to be a unique and effective catalyst for synthesizing secondary amines. The role of the K+ ion and the reaction intermediates were studied under control experiments and by theoretical calculations. The reaction was found to be general and tolerates a series of functional groups, providing a convenient method to synthesize N‐alkylated compounds.
- Subjects
TRANSITION metals; HYDROGEN; ALKYLATION; FUNCTIONAL groups; SECONDARY amines; POTASSIUM
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 11, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202301213