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- Title
B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>‐Catalyzed Aza‐Friedel–Crafts Reaction of Indolizines with 2‐Aryl‐3H‐indol‐3‐ones.
- Authors
Liu, Lei; He, Yonghui; Zou, Chang‐Peng; Ma, Tao; Qiao, Xiu‐Xiu; Jiang, Yuntao; Li, Ganpeng; Zhao, Xiao‐Jing
- Abstract
A Friedel–Crafts reaction of indolizines with 2‐aryl‐3H‐indol‐3‐ones catalyzed by B(C6F5)3 is described. This protocol gives access to indolizine derivatives that are valuable building blocks in synthetic and pharmaceutical chemistry. The reaction proceeds under mild conditions, affording various C2‐quaternary indolin‐3‐ones based on indolizine with high yields and regioselectivities. Moreover, the synthetic transformations of the target products were realized by N‐methylation and trifluoromethane sulfonation.
- Subjects
FRIEDEL-Crafts reaction; PHARMACEUTICAL chemistry; SULFONATION; FLUOROFORM
- Publication
European Journal of Organic Chemistry, 2023, Vol 26, Issue 35, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202300661