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- Title
Pathophysiology and Treatment of Radiation-Induced Brachial Plexopathy.
- Authors
Topkan, Erkan; Önal, H. Cem; Yavuz, M. Nur; Yavuz, A. Aydın
- Abstract
Radiation therapy is a well proven effective treatment modality in the management of various cancers. However, radiation therapy has potentially adverse effects on several tissues including central and peripheral nervous systems. Radiation- induced brachial plexopathy is a rare but challenging complication of RT in patients undergoing chest, axillary, and neck irradiation because of myriad of primary or malignant tumors of these region. It is a progressive disease state which may lead to devastating sensorial and motor malfunctions. Currently, there is no generally accepted treatment method, but non-narcotic and narcotics and anesthetic interventions for grade 1 and 2 lesions are suggested. In grade 3 and 4 injuries, surgical interventions to prevent fibrosis of the vascular supply to the nerves and to release nerves from fibrotic constrictions should be considered.
- Subjects
PATHOLOGICAL physiology; RADIOTHERAPY; CANCER treatment; SPINAL nerves; FIBROSIS; COLLAGEN diseases
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2008, Vol 18, Issue 3, p180
- ISSN
1306-133X
- Publication type
Article