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- Title
Intrathecal Methotrexate and Acute Neurotoxicity: A Painful Experience.
- Authors
Altinbaş, Akif; Çavuş, Şafak; Koca, Ebru; Çetiner, Deniz; Shorbagi, Ali; Haznedaroğlu, İbrahim C.
- Abstract
Intrathecal treatment with methotrexate, an essential chemotherapeutic for both prophylaxis and treatment of central nervous system involvement of leukemia, may be associated with local neurotoxicity and/or systemic toxicity. Signs of acute neurotoxicity include confusion, disorientation, seizures, aphasia, ataxia, dysarthria, paresis and even paralysis. Presented here is a case of a 58 year old patient with acute lymphoblastic leukemia who developed acute neurotoxicity after her 13th dose of intrathecal methotrexate. Available treatment options are also discussed.
- Subjects
METHOTREXATE; AMINOBENZOIC acids; IMMUNOSUPPRESSIVE agents; NEUROTOXICOLOGY; NEUROSCIENCES; BRAIN diseases; CENTRAL nervous system diseases
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2008, Vol 18, Issue 3, p163
- ISSN
1306-133X
- Publication type
Article