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- Title
Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell.
- Authors
Li, Lin; Xia, Yuting; Yuan, Shijie; Li, Fei; Xie, Xiaorong; Luo, Yuan; Yang, Xiang‐Ping; He, Ran
- Abstract
Iron plays a critical role in immune responses. However, its role in T helper cell differentiation and function remains poorly understood. In this study, it is shown that the restraint of iron availability through blocking CD71‐mediated iron endocytosis impaired the differentiation and pathogenicity of TH17 cells. Administrations of anti‐CD71 mAb could relieve the development of experimental autoimmune encephalomyelitis (EAE). Mechanistically, the iron deficiency due to the blocking of CD71 enhanced IL‐2 expression, which further restrained the differentiation of TH17 cells. Meanwhile, CD71 blockade impaired histone modifications of Il17 gene and reduced the recruitment of RORγt to Il17a locus. In sum, the findings reveal that iron plays a pivotal role in regulating TH17 cell differentiation and function in autoimmune diseases.
- Subjects
T helper cells; T cell differentiation; IRON; CELL physiology; CELL differentiation
- Publication
Journal of Leukocyte Biology, 2021, Vol 110, Issue 6, p1057
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1002/JLB.3MA0821-015R