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- Title
Fibromyalgia and periodontitis: Bidirectional associations in population-based 15-year retrospective cohorts.
- Authors
Ma, Kevin Sheng‐Kai; Lai, Jung‐Nien; Veeravalli, John Jims; Chiu, Lu‐Ting; Van Dyke, Thomas E.; Wei, James Cheng‐Chung; Ma, Kevin Sheng-Kai; Lai, Jung-Nien; Chiu, Lu-Ting; Wei, James Cheng-Chung
- Abstract
<bold>Background: </bold>To determine the bidirectional link between periodontitis and fibromyalgia.<bold>Methods: </bold>In this cohort study, 196,428 periodontitis patients and 196,428 propensity score-matched non-periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate the risk of fibromyalgia and survival analysis was adopted to assess the time-dependent effect of periodontitis on fibromyalgia. Subgroup analyses stratified by age, sex, and tracking period were conducted to identify susceptible populations. A parallel and symmetrical cohort that recruited 141,439 fibromyalgia patients and 141,439 propensity score-matched non-fibromyalgia controls ascertained the inverse effect of fibromyalgia on incident periodontitis.<bold>Results: </bold>Patients with periodontitis were more likely to develop fibromyalgia than non-periodontitis controls (HR = 1.42, 95% CI = 1.39-1.44, P < 0.001), which persisted in the survival analysis (log-rank test P < 0.0001). This effect was significant in both sexes and all age subgroups, and was particularly evident in males (HR = 1.52, 95% CI = 1.48-1.56, P < 0.001) and younger periodontitis patients (HR = 1.55, 95% CI = 1.50-1.60, P < 0.001). Fibromyalgia patients who never had periodontitis presented with greater risk for periodontitis over time (HR = 1.43, 95% CI = 1.40 - 1.45, P < 0.001; log-rank test P < 0.0001).<bold>Conclusions: </bold>Patients of both sexes and all age subgroups with periodontitis presented with a greater risk of fibromyalgia. Subgroups that were the most susceptible to periodontitis-associated fibromyalgia were periodontitis patients that were males and below 30 years old. Risks of periodontitis were also greater in fibromyalgia patients who never had periodontitis.
- Subjects
PERIODONTITIS; FIBROMYALGIA; CHRONIC pain; RHEUMATISM; FATIGUE (Physiology); INFLAMMATION
- Publication
Journal of Periodontology, 2022, Vol 93, Issue 6, p877
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1002/JPER.21-0256