We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Factor VIIa-Antithrombin complexes during cardiac surgery using cardiopulmonary bypass.
- Authors
DAVIDSON, S. J.; WOODHAMS, B.
- Abstract
Summary Antithrombin inhibits VIIa when bound to cellular tissue factor in the presence of heparin. VIIa concentrations increase within the surgical field during cardiopulmonary bypass surgery but decrease when measured in the patient. Using a new ELISA (Stago, Reading, UK), we measured VIIa-antithrombin complexes in patients undergoing cardiopulmonary bypass to determine whether antithrombin plays a physiological role in VIIa inhibition during cardiac surgery. Samples were taken from 13 adult patients undergoing cardiac surgery with cardiopulmonary bypass at the following time points: presurgery, postheparin, 20 min intervals during cardiopulmonary bypass and postprotamine. The presurgery concentrations of VIIa-antithrombin complexes were median of 52.7pm, and these rose postheparin bolus to a median of 110pM that was maintained throughout cardiopulmonary bypass and postprotamine administration. There is an approximate twofold increase in measurable VIIa-antithrombin complexes in patients undergoing cardiac surgery, which is apparent after heparin administration. Antithrombin appears to play an active role in VIIa inhibition during cardiac surgery.
- Subjects
BLOOD coagulation factors; CARDIOPULMONARY bypass; ENZYME-linked immunosorbent assay; FIBRIN; CARDIAC surgery; SURGICAL hemostasis; LONGITUDINAL method; PROBABILITY theory; CHEMICAL inhibitors
- Publication
International Journal of Laboratory Hematology, 2011, Vol 33, Issue 6, p614
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/j.1751-553X.2011.01331.x