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- Title
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
- Authors
Drinovac, V.; Bach-Rojecky, L.; Lacković, Z.
- Abstract
The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.
- Subjects
ANALGESICS; BOTULINUM toxin; GABA receptors; CENTRAL nervous system diseases; INFLAMMATION; BICUCULLINE; GABA agents; PREVENTION
- Publication
Journal of Neural Transmission, 2014, Vol 121, Issue 6, p665
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-013-1150-6