We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of acupuncture on cerebrovascular reserve in patients with acute cerebral infarction: protocol for a randomized controlled pilot study.
- Authors
Shaosong Wang; Tingting Ma; Linpeng Wang; Lu Liu; Huilin Liu; Bin Li; Yuanbo Fu; Wang, Shaosong; Ma, Tingting; Wang, Linpeng; Liu, Lu; Liu, Huilin; Li, Bin; Fu, Yuanbo
- Abstract
<bold>Background: </bold>The incidence of cerebral infarction has been growing year by year in China and around the world. According to clinical observation, acupuncture utilizing the "waking up the spirit" needling method is widely used in patients with cerebral infarction, though the underlying mechanisms remain unclear. Additionally, a number of studies have begun to focus on the relationship between cerebrovascular reserve (CVR) and cerebral infarction. The present study aims to investigate whether CVR is one of potential mechanisms underpinning this effect of acupuncture on patients with cerebral infarction.<bold>Methods: </bold>This is a single-centre, prospective, single-blinded, randomized controlled pilot study. Sixty eligible patients will be randomized into an intervention group (waking up the spirit acupuncture) and a control group (hand and foot 12-meridian acupuncture) in a 1:1 ratio. All treatments will be conducted once a day on weekdays followed by a 2-day rest period on the weekend, over a total treatment course of 2 weeks. The primary outcome measures are cerebrovascular reserve (CVR) capacity and Breath-holding Index (BHI) which will be evaluated at baseline and 2 weeks after the first acupuncture treatment, and the secondary outcome measures are National Institutes of Health Stroke Scale (NIHSS) and Barthel Index scores which will be used to further evaluate the efficacy of the intervention.<bold>Discussion: </bold>Cerebrovascular reserve is an independent risk factor for the occurrence, progression, and recurrence of cerebral infarction that requires attention. This trial aims to investigate whether acupuncture utilizing the waking up the spirit needling method can improve CVR capacity in patients with acute cerebral infarction, thus reducing NIHSS scores and preventing further progression of the disease. Furthermore, data and evidence gained from this study will be utilized in the development of future research projects regarding the effects of acupuncture in patients with acute cerebral infarction.<bold>Trial Registration: </bold>ISRCTN, ID: ISRCTN99117074 . Registered on 20 April 2016.
- Subjects
CHINA; CEREBRAL infarction; ACUPUNCTURE; CEREBROVASCULAR disease; CLINICAL trials; DISEASE progression; THERAPEUTICS; ACUPUNCTURE points; BLOOD flow measurement; CEREBRAL circulation; COMPARATIVE studies; FUNCTIONAL assessment; EXPERIMENTAL design; HEMODYNAMICS; LONGITUDINAL method; INFARCTION; RESEARCH methodology; MEDICAL cooperation; MEDICAL protocols; RESEARCH; TIME; TRANSCRANIAL Doppler ultrasonography; PILOT projects; EVALUATION research; BREATH holding; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; ACUTE diseases; BARTHEL Index; DIAGNOSIS
- Publication
Trials, 2017, Vol 18, p1
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-017-2013-5