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- Title
Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis.
- Authors
Gama, Ricardo Ribeiro; Carvalho, André Lopes; Filho, Adhemar Longatto; Scorsato, Anderson Paulo; López, Rossana V. Mendoza; Rautava, Jaana; Syrjänen, Stina; Syrjänen, Kari
- Abstract
<bold>Background: </bold>Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies.<bold>Objective: </bold>To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in LSCC.<bold>Methods: </bold>Literature was searched from January 1964 until March 2015. The effect size was calculated as event rates (95% confidence interval [CI]), with homogeneity testing using Cochran's Q and I(2) statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size. Potential publication bias was estimated using funnel plot symmetry.<bold>Results: </bold>One hundred seventy nine studies were eligible, comprising a sample size of 7,347 LSCCs from different geographic regions. Altogether, 1,830 (25%) cases tested HPV-positive considering all methods, with effect size of 0.269 (95% CI: 0.242 to 0.297; random-effects model). In meta-analysis stratified by the 1) HPV detection technique and 2) geographic study origin, the between-study heterogeneity was significant only for geographic origin (P = .0001). In meta-regression, the HPV detection method (P = .876) or geographic origin (P = .234) were not significant study-level covariates. Some evidence for publication bias was found only for studies from North America and those using non-polymerase chain reaction methods, with a marginal effect on adjusted point estimates for both.<bold>Conclusions: </bold>Variability in HPV detection rates in LSCC is explained by geographic origin of study but not by HPV detection method. However, they were not significant study-level covariates in formal meta-regression.<bold>Level Of Evidence: </bold>NA.
- Subjects
LARYNGEAL cancer; SQUAMOUS cell carcinoma; ONCOGENIC DNA viruses; DNA viruses; LARYNGEAL tumors; META-analysis; PAPILLOMAVIRUS diseases; PAPILLOMAVIRUSES; IMPACT of Event Scale; DISEASE complications
- Publication
Laryngoscope, 2016, Vol 126, Issue 4, p885
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.25738