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- Title
Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion.
- Authors
Franzi, Elisa; Mathez, Gregory; Dinant, Soraya; Deloizy, Charlotte; Kaiser, Laurent; Tapparel, Caroline; Le Goffic, Ronan; Cagno, Valeria
- Abstract
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment.
- Subjects
INFLUENZA viruses; HEMAGGLUTININ; ESTROGEN; VIRUS diseases; RESPIRATORY infections; AVIAN influenza
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 20, p15382
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242015382