We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modulation of the Endomembrane System by the Anticancer Natural Product Superstolide/ZJ-101.
- Authors
Sanchez, Phillip R.; Head, Sarah A.; Qian, Shan; Qiu, Haibo; Roy, Avishek; Jin, Zhendong; Zheng, Wei; Liu, Jun O.
- Abstract
Marine natural products represent a unique source for clinically relevant drugs due to their vast molecular and mechanistic diversity. ZJ-101 is a structurally simplified analog of the marine natural product superstolide A, isolated from the New Caledonian sea sponge Neosiphonia Superstes. The mechanistic activity of the superstolides has until recently remained a mystery. Here, we have identified potent antiproliferative and antiadhesive effects of ZJ-101 on cancer cell lines. Furthermore, through dose–response transcriptomics, we found unique dysregulation of the endomembrane system by ZJ-101 including a selective inhibition of O-glycosylation via lectin and glycomics analysis. We applied this mechanism to a triple-negative breast cancer spheroid model and identified a potential for the reversal of 3D-induced chemoresistance, suggesting a potential for ZJ-101 as a synergistic therapeutic agent.
- Subjects
MARINE natural products; NATURAL products; TRIPLE-negative breast cancer; SPONGES (Invertebrates); GLYCOMICS; INTRACELLULAR membranes
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 11, p9575
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24119575