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- Title
Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery.
- Authors
't Hart, Bert A.; Laman, Jon D.; Kap, Yolanda S.
- Abstract
The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important lessons can be learned from a critical reassessment of failed drugs in the animal model, which can help improve the animal model and better understand the targeted disease.
- Subjects
ANIMAL models of multiple sclerosis; MULTIPLE sclerosis treatment; DRUG development; ENCEPHALOMYELITIS; CLINICAL trials; AUTOIMMUNE diseases
- Publication
Clinical Pharmacology & Therapeutics, 2018, Vol 103, Issue 2, p262
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.801