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- Title
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer.
- Authors
Ren, J. G.; Man, Q. W.; Zhang, W.; Li, C.; Xiong, X. P.; Zhu, J. Y.; Wang, W. M.; Sun, Z. J.; Jia, J.; Zhang, W. F.; Zhao, Y. F.; Chen, G.; Liu, B.
- Abstract
Numerous studies have demonstrated that circulating microparticles (MPs) play important roles in a variety of diseases (e.g., atherosclerosis, hypertension, and diabetes), but the association between circulating MPs and oral squamous cell carcinoma (OSCC) remains largely unknown. In the present study, the circulating platelet-derived MPs (PMPs) in 63 patients with OSCC, 22 patients with infected keratocystic odontogenic tumor, and 31 healthy volunteers were characterized and quantified by flow cytometric analysis. The coagulation function of patients with OSCC was correspondingly evaluated. Meanwhile, the inflammation-related cytokines were detected in plasma by enzyme-linked immunosorbent assay and in tumor tissues by immunohistochemistry. Our results showed that the plasma level of circulating PMPs was significantly higher in OSCC patients compared with healthy volunteers and patients with infected keratocystic odontogenic tumor, and they showed positive correlation with the increased level of fibrinogen. Moreover, the coagulation time was significantly shorter after the MPs were added to the MP-free plasma. Most important, the levels of interleukin 6 and tumor necrosis factor α in plasma and tumor tissues were significantly increased in OSCC patients, which were closely correlated with the elevated level of circulating PMPs. In summary, this study suggests that the elevated level of circulating PMPs, showing close correlation with the secretion of inflammation-related factors, may contribute to the increased procoagulant activity in patients with OSCC.
- Subjects
ORAL cancer; PLATELET-derived growth factor; BLOOD coagulation; FLOW cytometry; TUMOR necrosis factors; BLOOD platelets; CELL membranes; COMPARATIVE studies; CYTOKINES; FIBRINOGEN; INTERLEUKINS; RESEARCH methodology; MEDICAL cooperation; MOUTH tumors; ODONTOGENIC tumors; RESEARCH; SQUAMOUS cell carcinoma; TUMOR classification; EVALUATION research
- Publication
Journal of Dental Research, 2016, Vol 95, Issue 1, p87
- ISSN
0022-0345
- Publication type
journal article
- DOI
10.1177/0022034515592593