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- Title
Serum level of C-reactive protein is a confounder factor as a predictor of post-surgical complications in patients undergoing coronary artery bypass graft.
- Authors
Tejerina, Teresa; Gordillo-Moscoso, Antonio; Redondo, Santiago; Torrejón, Maria; Cárdenas, Cruz; Reguillo, Fernando; Ruiz, Emilio
- Abstract
Introduction: Plasma C-reactive protein (C-RP) has been postulated as an independent prognostic factor for cardiovascular events . Aim: To determine whether serum levels of C-RP behave as a prognostic factor of postoperative complications after CABG. Patients and methods: A cohort of patients was recruited from who underwent CABG. The best regression models were obtained with a stepwise approach. The composite end-point was: development of cardiac, renal and pulmonary complications or death within the first 30 days after CABG. Results: Hundred sixteen patients were recruited; 17 (15%) women, 51 (43%) diabetics, 64 (55%) hypertensives, 69 (59%) hyperlipidemics, and 38 (33%) currently smokers. The multiple and logistic multivariate analysis showed that both C-RP levels and the development of complications were correlated with the presence of a previous Myocardial Infarction (MI) within the 30 days prior CABG. C-RP were also correlated to Age, Fibrinogen and Inlerleukin-6 levels. In addition, complication were predicted by Euroscore scale punctuation and currently smoking. Conclusion: An early Myocardial Infarction is a key parameter related with CR-P and with early post-surgical complications in CABG patients. Plasma levels of C-RP itself seem to be a confounder factor as predictor of such complications.
- Subjects
C-reactive protein; SERUM; BLOOD plasma; COMPLICATIONS of cardiac surgery; CORONARY artery bypass; MYOCARDIAL infarction; ACUTE phase proteins
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA804
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a804