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- Title
Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis.
- Authors
Berbée, Jimmy F. P.; Van der Hoogt, Caroline C.; Kleemann, Robert; Schippers, Emile F.; Kitchens, Richard L.; Van Dissel, Jaap T.; Bakker-Woudenberg, Irma A. J. M.; Havekes, Louis M.; Rensen, Patrick C. N.
- Abstract
The article presents a study which examined how apolipoprotein CI (apoCI) stimulates the response to lipopolysaccharide (LPS) and reduces mortality in Gram-negative sepsis. Lipoproteins like high-density lipoprotein have been shown to bind LPS and to protect against sepsis. The results of a sequence alignment analysis showed that apoCI contains a KVKEKLK motif in its C-terminal domain that is highly homologous to the LPS-binding sequence of established LPS-binding proteins.
- Subjects
APOLIPOPROTEINS; BLOOD lipoproteins; GRAM-negative bacterial diseases; SEPSIS; LIPOPROTEINS
- Publication
FASEB Journal, 2006, Vol 20, Issue 12, p2162
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-5639fje