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- Title
Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm.
- Authors
Cowan, Kyle Northcote; Leung, Wesley C. Y.; Mar, Christopher; Bhattacharjee, Rakesh; Yonghong Zhu; Rabinovitch, Marlene
- Abstract
Investigates whether vascular smooth muscle cell (SMC) apoptosis is coordinated with degradation of elastin in collagen gels. Nature of the elastin degrading enzyme released by apoptotic SMC; Role of caspases in mediating apoptosis-associated extracellular matrix degradation; Impact of caspase inhibitors on elastolysis by apoptotic SMC.
- Subjects
SMOOTH muscle; APOPTOSIS; CELL death; COLLOIDS; ELASTIN; EXTRACELLULAR matrix proteins
- Publication
FASEB Journal, 2005, Vol 19, Issue 13, p1848
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-3706fje