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- Title
Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients.
- Authors
Park, Jong-Sook; Heo, Jeong-Seok; Chang, Hun Soo; Choi, Inseon S.; Kim, Mi-Kyeong; Lee, Jong-Uk; Park, Byung Lae; Shin, Hyoung Doo; Park, Choon-Sik
- Abstract
Member RAS oncogene family ( RAB1A), a member of the RAS oncogene family, cycles between inactive GDP-bound and active GTP-bound forms regulating vesicle transport in exocytosis. Thus, functional alterations of the RAB1A gene may contribute to aspirin intolerance in asthmatic sufferers. To investigate the relationship between single-nucleotide polymorphisms (SNPs) in the RAB1A gene and aspirin-exacerbated respiratory disease (AERD), asthmatics ( n=1197) were categorized into AERD and aspirin-tolerant asthma (ATA). All subjects were diagnosed as asthma on the basis of the Global Initiative for Asthma (GINA) guidelines. AERD was defined as asthmatics showing 15% or greater decreases in forced expiratory volume in one second (FEV1) or naso-ocular reactions by the oral acetyl salicylic acid (ASA) challenge (OAC) test. In total, eight SNPs were genotyped. Logistic regression analysis identified that the minor allele frequency of +14444 T>G and +41170 C>G was significantly higher in the AERD group ( n=181) than in the ATA group ( n=1016) ( p=0.0003−0.03). Linear regression analysis revealed a strong association between the SNPs and the aspirin-induced decrease in FEV1 ( p=0.0004−0.004). The RAB1A gene may play a role in the development of AERD in asthmatics and the genetic polymorphisms of the gene have the potential to be used as an indicator of this disease.
- Subjects
RAS oncogenes; SINGLE nucleotide polymorphisms; ASPIRIN; ASTHMATICS; EXOCYTOSIS; SALICYLIC acid; LOGISTIC regression analysis
- Publication
DNA & Cell Biology, 2014, Vol 33, Issue 3, p155
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/dna.2013.2213