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- Title
MicroRNA expression profiling on arrays enhanced with locked nucleic acids.
- Authors
Roberts, Peter
- Abstract
Here we describe a new array system (miRCURYTM LNA Array) for global microRNA (miRNA) profiling of biological samples. The miRCURY LNA Array system uses locked nucleic acid (LNATM), a high-affinity nucleotide analog, to enhance the array capture probes, giving them high sensitivity and excellent selectivity for miRNA targets. We have simultaneously developed a straightforward method for labeling miRNAs in a sample. As a result, the miRCURY LNA Array system can provide sensitiveand accurate profiling of miRNAs while requiring less sample and keeping sample handling stepsto a minimum.
- Subjects
RNA; NUCLEOTIDES; BIOLOGY; NUCLEIC acids; RIBOSE
- Publication
Nature Methods, 2006, Vol 3, Issue 4, p1
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth869