We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Signaling pathway switch in breast cancer.
- Authors
Guille, Arnaud; Chaffanet, Max; Birnbaum, Daniel
- Abstract
Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells.
- Subjects
BREAST cancer; CANCER cell proliferation; CARCINOGENESIS; CELL cycle regulation; GENES
- Publication
Cancer Cell International, 2013, Vol 13, Issue 1, p1
- ISSN
1475-2867
- Publication type
Article
- DOI
10.1186/1475-2867-13-66