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- Title
Clinical-Pathological Conference Series from the Medical University of Graz: Case No 173: A 77-year-old patient with adenocarcinoma of the prostate, liver metastases and watery diarrhea.
- Authors
Fabian, Elisabeth; Kump, Patrizia; Schiller, Dietmar; Brcic, Iva; Gruber, Christine; Heitz, Philipp U.; Klöppel, Günter; Lipp, Rainer W.; Moinfar, Farid; Schöfl, Rainer; Fickert, Peter; Krejs, Guenter J.
- Abstract
Final diagnosis VIPoma, also termed pancreatic cholera, Verner-Morrison syndrome or WDHH (watery diarrhea, hypokalemia, hypochlorhydria) syndrome due to VIP-expressing tumor tissue in the liver with unknown primary but most likely originating from neuroendocrine differentiation in posttreatment prostate cancer. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. Keywords: VIPoma; Pancreatic cholera; Verner-Morrison syndrome; WDHH (watery diarrhea, hypokalemia, hypochlorhydria) syndrome; Hypokalemia EN VIPoma Pancreatic cholera Verner-Morrison syndrome WDHH (watery diarrhea, hypokalemia, hypochlorhydria) syndrome Hypokalemia 515 522 8 05/17/21 20210501 NES 210501 Information Information on Clinical-Pathological Conferences from the Medical University of Graz are also available under https://www.medunigraz.at/cpc-klinischpathologischekonferenz/ (in German). One of the key symptoms in the discussed patient is a 2-month history of watery diarrhea (4-6 weeks of diarrhea is defined as chronic diarrhea), which may be due to osmotic, secretory, functional or inflammatory causes; however, since endoscopy with biopsies was unremarkable in the discussed patient diagnoses, such as celiac disease, microscopic colitis, inflammatory bowel disease and eosinophilic enteritis can be ruled out.
- Subjects
PROSTATE cancer; MEDULLARY thyroid carcinoma; LIVER metastasis; DIARRHEA; AIDS; PROSTATE; ISLANDS of Langerhans tumors
- Publication
Wiener Klinische Wochenschrift, 2021, Vol 133, Issue 9/10, p515
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-020-01791-x