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- Title
Gastric perforation due to nivolumab related tumor flare.
- Authors
Malipatil, Basawantrao; Palleti, Adarsh; Verma, Namita; Katti, Sanjeev; Verma, Namita Sinha; Katti, Sanjeev V
- Abstract
Tumor flare is a recognized complication of Nivolumab immunotherapy.[[1]],[[2]] Currently there are no diagnostic tools to differentiate tumor flare from disease progression. This indicates that the gastric perforation was an effect of Nivolumab induced tumor flare rather than disease progression. Severe colitis and colonic perforation has been described with Ipilimumab immunotherapy, but not with Nivolumab.[[3]],[[4]] The underlying mechanism of tumor flare related gastric perforation in the present case is not clear and could possibly be related to tumor necrosis.
- Subjects
TUMORS; FLARES; SYMPTOMS
- Publication
Indian Journal of Cancer, 2019, Vol 56, Issue 4, p374
- ISSN
0019-509X
- Publication type
case study
- DOI
10.4103/ijc.IJC_776_18