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- Title
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer.
- Authors
Mete Ural, Ülkü; Şehitoğlu, İbrahim; Bayoğlu Tekin, Yeşim; Kir Şahin, Figen
- Abstract
Aim Neutrophil-to-lymphocyte ratio ( NLR), platelet-to-lymphocyte ratio ( PLR) and platelet distribution width ( PDW) may indicate the systemic inflammatory response associated with various cancers. We aimed to investigate the relationship between NLR, PLR, PDW and endometrial pathologies including hyperplasia and cancer. Methods In this study, 472 cases who underwent endometrial biopsy were included. Three groups were constituted with respect to biopsy results: group 1, endometrial cancer patients ( n = 54); group 2, endometrial hyperplasia patients ( n = 152); and group 3, patients with normal biopsy results ( n = 281). White blood cell and platelet counts as well as NLR, PLR and PDW recorded from complete blood counts obtained on the same day of biopsy were compared in the three groups. Results Endometrial cancer patients were significantly older than the cases in the other two groups ( P < 0.001). The NLR in group 1 was significantly higher than group 3 ( P = 0.02). However, there was no difference between the three groups with respect to PLR ( P = 0.167). PDW was increased in group 1 compared to group 3 ( P < 0.001). Conclusion Results of our study have shown that NLR, PLR and PDW are simple, readily available and robust inflammatory markers that may be used in the management of endometrial pathologies. However, the actual predictive potential of these biomarkers still warrants further trials.
- Subjects
HYPERPLASIA; BIOMARKERS; ENDOMETRIAL diseases; MATHEMATICAL statistics; NEUTROPHILS; NONPARAMETRIC statistics; ENDOMETRIAL tumors; PARAMETERS (Statistics); DESCRIPTIVE statistics; LYMPHOCYTE count; PLATELET count; MANN Whitney U Test; KRUSKAL-Wallis Test
- Publication
Journal of Obstetrics & Gynaecology Research, 2015, Vol 41, Issue 3, p445
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.12536