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- Title
Quantification of myocardial blood flow using non-ECG-triggered MR imaging.
- Authors
Chen, David; Sharif, Behzad; Dharmakumar, Rohan; Thomson, Louise E.J.; Bairey Merz, C. Noel; Berman, Daniel S.; Li, Debiao
- Abstract
Purpose MR myocardial perfusion imaging is dependent on reliable electrocardiogram (ECG) triggering for accurate measurement of myocardial blood flow (MBF). A non-ECG-triggered method for quantitative first-pass imaging may improve clinical feasibility in patients with poor ECG signal. The purpose of this study is to evaluate the feasibility of a non-ECG-triggered method for myocardial perfusion imaging in a single slice. Methods The proposed non-ECG-triggered technique uses a saturation-recovery magnetization preparation and golden-angle radial acquisition for integrated arterial input function (AIF) measurement. Image based self-gating with a temporal resolution of 42.6 ms is used to generate a first-pass image series with consistent cardiac phase. The AIF is measured using beat-by-beat T1 estimation of the ventricular blood pool. The proposed technique was performed on 14 healthy volunteers and compared against a conventional ECG-triggered dual-bolus acquisition. Results The proposed method produced MBF with no significant difference compared with ECG-triggered technique (mean of 0.63 ± 0.22 mL/min/g to 0.73 ± 0.21 mL/min/g). Conclusion We have developed a non-ECG-triggered perfusion imaging method with T1 based measurement of the AIF in a single slice. In this preliminary study, our results demonstrate that MBF measured using the proposed method is comparable to the conventional ECG-triggered method. Magn Reson Med 74:765-771, 2015. © 2014 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2015, Vol 74, Issue 3, p765
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.25451