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- Title
Rickettsia parkeri infections diagnosed by eschar biopsy, Virginia, USA.
- Authors
Kelman, Pamela; Thompson, Chelsea Wright; Hynes, Wayne; Bergman, Christian; Lenahan, Cameron; Brenner, Joel S.; Brenner, Michelle G.; Goodman, Benjamin; Borges, Demetria; Filak, Michael; Gaff, Holly
- Abstract
Background: Infection with Rickettsia parkeri is an emerging tick-borne illness, often accompanied by fever and an eschar at the site of tick attachment. We present three cases of R. parkeri in Virginia residents.Case presentations: Case 1 presented initially afebrile, failed to seroconvert to rickettsial antigens, and was diagnosed by DNA testing of the eschar. Case 2 presented febrile with eschar, no serologies were performed, and was diagnosed by DNA testing of the eschar. Case 3 presented febrile with eschar, serologies were negative for rickettsial antigens, and was diagnosed by DNA testing of the eschar.Conclusion: DNA testing of eschars represents an under-utilized diagnostic test and may aid in cases where the diagnosis is not made clinically.
- Subjects
VIRGINIA; RICKETTSIAL disease diagnosis; ANTIGENS; BIOPSY; BITES &; stings; INSECTS; RICKETTSIAL diseases; ROCKY Mountain spotted fever; TICKS; GENETIC testing; DISEASE complications
- Publication
Infection, 2018, Vol 46, Issue 4, p559
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-018-1120-x