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- Title
Future Prospective of Radiopharmaceuticals from Natural Compounds Using Iodine Radioisotopes as Theranostic Agents.
- Authors
Nurhidayah, Wiwit; Setyawati, Luthfi Utami; Daruwati, Isti; Gazzali, Amirah Mohd; Subroto, Toto; Muchtaridi, Muchtaridi
- Abstract
Natural compounds provide precursors with various pharmacological activities and play an important role in discovering new chemical entities, including radiopharmaceuticals. In the development of new radiopharmaceuticals, iodine radioisotopes are widely used and interact with complex compounds including natural products. However, the development of radiopharmaceuticals from natural compounds with iodine radioisotopes has not been widely explored. This review summarizes the development of radiopharmaceuticals from natural compounds using iodine radioisotopes in the last 10 years, as well as discusses the challenges and strategies to improve future discovery of radiopharmaceuticals from natural resources. Literature research was conducted via PubMed, from which 32 research articles related to the development of natural compounds labeled with iodine radioisotopes were reported. From the literature, the challenges in developing radiopharmaceuticals from natural compounds were the purity and biodistribution. Despite the challenges, the development of radiopharmaceuticals from natural compounds is a golden opportunity for nuclear medicine advancement.
- Subjects
IODINE radioisotopes; IODINE compounds; RADIOPHARMACEUTICALS; NUCLEAR medicine; COMPLEX compounds
- Publication
Molecules, 2022, Vol 27, Issue 22, p8009
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27228009