We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of the local and systemic pattern of sensitization to allergens in patients with adenotonsillar hypertrophy.
- Authors
Mahavar, Neda; Asghari, Masoud; Mofatteh, Mohammadreza; Jaberi, Sanaz; Erfanian, Nafiseh; Chahkandi, Mahboobeh; Fereidouni, Mohammad
- Abstract
Purpose: Adenotonsillar hypertrophy (ATH) is a medical condition characterized by the enlargement or swelling of the tonsils. The role of allergy in ATH has not been persuasively evidenced. Therefore, we investigated the state of humoral immunity and the presence of specific immunoglobulin E (sIgE) in tissues and sera in children suffering from TH. Methods: According to the skin prick test (SPT) result, 44 ATH children were divided into the atopic and non-atopic groups. The level of sIgE against 30 inhalants and food allergens in the sera and tissue homogenates was measured by a commercial allergy immunoblotting kit. In addition, we evaluated the following variables in both tonsillar tissue homogenates and serum: total IgE, IgA, IgM, IgG, and tissue eosinophil counts. Results: Our results showed that 21 (47.7%) of patients with ATH were sensitized to at least one allergen in the adenotonsillar sample and/or sera. Only two patients were negative for sIgE in the atopic group, but in the non-atopic group, only one had positive sIgE results. In the atopic group, 19 (86.4%) patients had positive sIgE in tonsillar tissues, and 18 (81.8%) had sensitized serum. There were no statistical differences in the case of other antibodies except IgE levels between the two groups. The average eosinophilic count was significantly higher in atopic patients than in the non-atopic group. Conclusion: The results of this study support the role of allergy in the pathogenesis of ATH and confirmed local allergic inflammation in tonsillar tissue.
- Subjects
IMMUNOGLOBULIN E; ALLERGENS; HYPERTROPHY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M
- Publication
European Archives of Oto-Rhino-Laryngology, 2024, Vol 281, Issue 8, p4231
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-024-08550-y