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- Title
Medulloblastoma Metastatic to the Suprasellar Region at Diagnosis: A Report of Six Cases with Clinicopathologic Correlation.
- Authors
Helton, Kathleen J.; Gajjar, Amar; Hill, D. Ashley; Boop, Fredrick A.; Kun, Larry E.; Langston, James W.
- Abstract
The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4–8.8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.Copyright © 2002 S. Karger AG, Basel
- Subjects
MEDULLOBLASTOMA; CEREBELLAR tumors; GLIOMAS; METASTASIS; TUMORS
- Publication
Pediatric Neurosurgery, 2002, Vol 37, Issue 3, p111
- ISSN
1016-2291
- Publication type
Article
- DOI
10.1159/000064392