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- Title
Synthesis of 2-aminochromene derivatives from 1-(2-imino-2H-chromen-3-yl)pyridin-1-ium perchlorates and nitromethane in basic medium.
- Authors
Storozhenko, Olga А.; Yue, Xiaoyi; Festa, Alexey А.; Varlamov, Alexey А.; Voskressensky, Leonid G.
- Abstract
Novel 2-amino-4-(nitromethylidene)chromenes were obtained as a result of the reaction of 1-(2-imino-2H-chromen-3-yl)pyridinium perchlorates and nitromethane by the action of DBU at reflux in trifluoroethanol. The starting 2-iminochromenes are readily accessible from the corresponding salicylic aldehydes and quaternary cyanomethyl pyridinium salts. The reaction is tolerant to substituents of different nature (alkyl, alkoxy, halogen); a limitation is the presence of strong electron-withdrawing substituents in the benzene ring of chromene. During the reaction, the products precipitate and can be isolated by filtration.
- Subjects
NITROMETHANE; PERCHLORATES; ALDEHYDES; BENZENE; FILTERS &; filtration
- Publication
Chemistry of Heterocyclic Compounds, 2020, Vol 56, Issue 9, p1161
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-020-02793-3