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- Title
Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides.
- Authors
Aksenov, Nicolai A.; Arutiunov, Nikolai A.; Kirillov, Nikita K.; Aksenov, Dmitrii A.; Aksenov, Alexander V.; Rubin, Michael
- Abstract
Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with semicarbazides or thiosemicarbazides allows to access 2-amino-1,3,4-oxadiazoles and 2-amino-1,3,4-thiadiazoles, respectively.
- Subjects
NITROALKANES; POLYPHOSPHORIC acid; BRONSTED acids; THIADIAZOLES
- Publication
Chemistry of Heterocyclic Compounds, 2020, Vol 56, Issue 8, p1067
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-020-02775-5