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- Title
FIBRINOLYSIS FOLLOWING ELECTRICALLY INDUCED CONVULSIONS.
- Authors
Fantl, P.; Simon, Shirley E.
- Abstract
The application in this hospital of alternating current for electro-convulsive therapy (E.C.T.) and electronarcosis in certain mental disturbances afforded the opportunity of investigating the effects of this form of therapy on some of the components of the blood. Schütz (1942) observed in vitro a delayed coagulation of blood following application of a weak direct current. Brecht and Kummer (1943) noted a leucocytosis immediately after electrical shock; there was no alteration of blood sugar or protein. Spiegel-Adolf, Spiegel et al. (1945) reported that following the application of a 60 cycle current at 30 volts for 1-2 seconds there were changes in cerebro-spinal fluid suggesting the breakdown of nuclear substances. This statement, however, has since been contradicted by M. H. Hack (1947). Huddleson (1946) observed haemorrhages in the central nervons system in rats following electrical shock. Trojaniello (1947) indicated that dogs subjected to electrical shock by alternating current at 120 volts for a fraction of a second, showed no changes in blood lipase and diastase, but that pbosphatase activity decreased for about 12 hours. Delay and Soulairac (1943) observed, following E.C.T. in human subjects, a transient increase in blood albumin, and occasionally a slight increase in the globulin fraction. There was a concomitant increase of blood calcium and inorganic phosphate. Further, hyperglycemia, leucocytosis, and a decrease in the alkali reserve were demonstrable.
- Subjects
ELECTROCONVULSIVE therapy; ELECTROTHERAPEUTICS; ELECTRIC anesthesia; FIBRINOLYSIS; BLOOD coagulation; SHOCK therapy; LEUCOCYTOSIS; HYPERGLYCEMIA
- Publication
Australian Journal of Experimental Biology & Medical Science, 1948, Vol 26, Issue 6, p521
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1948.54