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- Title
ATP/azobenzene-guanidinium self-assembly into fluorescent and multi-stimuli-responsive supramolecular aggregates.
- Authors
Abodja, Olivier; Touati, Nadia; Morel, Mathieu; Rudiuk, Sergii; Baigl, Damien
- Abstract
Building stimuli-responsive supramolecular systems is a way for chemists to achieve spatio-temporal control over complex systems as well as a promising strategy for applications ranging from sensing to drug-delivery. For its large spectrum of biological and biomedical implications, adenosine 5'-triphosphate (ATP) is a particularly interesting target for such a purpose but photoresponsive ATP-based systems have mainly been relying on covalent modification of ATP. Here, we show that simply mixing ATP with AzoDiGua, an azobenzene-guanidium compound with photodependent nucleotide binding affinity, results in the spontaneous self-assembly of the two non-fluorescent compounds into photoreversible, micrometer-sized and fluorescent aggregates. Obtained in water at room temperature and physiological pH, these supramolecular structures are dynamic and respond to several chemical, physical and biological stimuli. The presence of azobenzene allows a fast and photoreversible control of their assembly. ATP chelating properties to metal dications enable ion-triggered disassembly and fluorescence control with valence-selectivity. Finally, the supramolecular aggregates are disassembled by alkaline phosphatase in a few minutes at room temperature, resulting in enzymatic control of fluorescence. These results highlight the interest of using a photoswitchable nucleotide binding partner as a self-assembly brick to build highly responsive supramolecular entities involving biological targets without the need to covalently modify them. Building stimuli-responsive supramolecular materials enables spatiotemporal control over complex systems, and is a promising strategy for a range of applications. Here, mixing adenosine 5'-triphosphate (ATP) with an azobenzene-guanidium compound possessing photodependent nucleotide binding affinity is shown to result in the spontaneous photo-reversible self-assembly of these compounds into micrometer-sized fluorescent aggregates that display dynamic responses to several chemical, physical and biological stimuli.
- Subjects
ADENOSINE triphosphate; ADENOSINES; DRUG target; WATER temperature; ALKALINE phosphatase; CHEMISTS; FLUORESCENCE; AZOBENZENE
- Publication
Communications Chemistry, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3669
- Publication type
Article
- DOI
10.1038/s42004-024-01226-y