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- Title
Antimalarial drug discovery: efficacy models for compound screening.
- Authors
Fidock, David A.; Rosenthal, Philip I.; Croft, Simon L.; Brun, Reto; Nwaka, Solomon
- Abstract
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to develop safe and affordable new drugs to counter the spread of malaria parasites that are resistant to existing agents. Drug efficacy, pharmacology and toxicity are important parameters in the selection of compounds for development, yet little attempt has been made to review and standardize antimalarial drug-efficacy screens. Here, we suggest different in vitro and in vivo screens for antimalarial drug discovery and recommend a streamlined process for evaluating new compounds on the path from drug discovery to development.
- Subjects
ANTIMALARIALS; DRUG efficacy; ANTIPARASITIC agents; PHARMACOLOGY; MEDICAL sciences; DRUG development
- Publication
Nature Reviews Drug Discovery, 2004, Vol 3, Issue 6, p509
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd1416