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- Title
The Role of Comorbidities in Cardioprotection.
- Authors
Sack, Michael N.; Murphy, Elizabeth
- Abstract
Cardioprotective strategies such as pre- and postconditioning result in a robust reduction in infarct size in young, healthy male animals. However, there are data suggesting that the protection is diminished in animals with comorbidities such as hypertension, hypercholesterolemia, and diabetes. It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials.
- Subjects
COMORBIDITY; METABOLIC syndrome; ISCHEMIA; REPERFUSION injury; HEART diseases
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2011, Vol 16, Issue 3/4, p267
- ISSN
1074-2484
- Publication type
Article
- DOI
10.1177/1074248411408313