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- Title
Development of a 4-D digital mouse phantom for molecular imaging research
- Authors
Segars, William. P.; Tsui, Benjamin M.W.; Frey, Eric C.; Johnson, G. Allan; Berr, Stuart S.
- Abstract
<bold>Purpose: </bold>We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research.<bold>Methods: </bold>Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained from normal mice. Pilot simulation studies in single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) were performed to demonstrate the utility of the phantom.<bold>Results: </bold>NURBS are an efficient and flexible way to accurately model the anatomy and cardiac and respiratory motions for a realistic 4-D digital mouse phantom. The phantom is capable of producing realistic molecular imaging data from which imaging devices and techniques can be evaluated.<bold>Conclusion: </bold>The phantom provides a unique and useful tool in molecular imaging research. It can be used in the development of new imaging instrumentation, image acquisition strategies, and image processing and reconstruction methods.
- Subjects
MAGNETIC resonance imaging; IMAGING systems; TOMOGRAPHY; IMAGE processing; DIAGNOSTIC imaging; MICE anatomy; MICE physiology; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; COMPUTED tomography; HUMAN anatomical models; DIGITAL image processing; RESEARCH methodology; MEDICAL cooperation; IMAGING phantoms; RESEARCH; EVALUATION research; SINGLE-photon emission computed tomography
- Publication
Molecular Imaging & Biology, 2004, Vol 6, Issue 3, p149
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1016/j.mibio.2004.03.002